Which drug is listed as an intraarterial chemotherapy example?

Which drug is listed as an intraarterial chemotherapy example?

• A. Decarbazine
• B. Bleomycin
• C. Methotrexate
• D. Capecitabine

Answer: (A)

Delivering chemotherapy directly into the artery that feeds a tumor creates a high local drug concentration in the tumor while limiting systemic exposure. Dacarbazine is used in some regional or intraarterial infusion protocols to treat localized disease, making it a representative example of intraarterial chemotherapy. The other agents are more commonly given by systemic routes (capecitabine is an oral prodrug of 5-FU; methotrexate is typically IV or intrathecal; bleomycin is usually systemic or used in other local therapies), so they are less typical examples of intraarterial chemotherapy.

Delivering chemotherapy directly into the artery that feeds a tumor creates a high local drug concentration in the tumor while limiting systemic exposure. Dacarbazine is used in some regional or intraarterial infusion protocols to treat localized disease, making it a representative example of intraarterial chemotherapy. The other agents are more commonly given by systemic routes (capecitabine is an oral prodrug of 5-FU; methotrexate is typically IV or intrathecal; bleomycin is usually systemic or used in other local therapies), so they are less typical examples of intraarterial chemotherapy.